Biomarkers associating endothelial Dysregulation in pediatric-onset systemic lupus erythematous
Identifieur interne : 000A00 ( Main/Exploration ); précédent : 000999; suivant : 000A01Biomarkers associating endothelial Dysregulation in pediatric-onset systemic lupus erythematous
Auteurs : Wan-Fang Lee [Taïwan] ; Chao-Yi Wu [Taïwan] ; Huang-Yu Yang [Taïwan] ; Wen-I Lee [Taïwan] ; Li-Chen Chen [Taïwan] ; Liang-Shiou Ou [Taïwan] ; Jing-Long Huang [Taïwan]Source :
- Pediatric Rheumatology Online Journal [ 1546-0096 ] ; 2019.
Abstract
Endothelium is a key element in the regulation of vascular homeostasis and its alteration can lead to the development of vascular diseases. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with potential extensive vascular lesions, involving skin vessels, renal glomeruli, cardiovascular system, brain, lung alveoli, gastrointestinal tract vessels and more. We aimed to assess endothelial dysregulation related biomarkers in pediatric-onset SLE (pSLE) patient serum and elucidate its correlation with their clinical features, laboratory parameters, and the overall disease activity.
Disease activities were evaluated by SLE disease activity index (SLEDAI). Patient characteristics were obtained by retrospective chart review. Six biomarkers associated with endothelial dysregulation, including Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), Tie2, Vascular endothelial growth facto
This study comprised 118 pSLE patients. Data from 40 age-matched healthy controls were also obtained. The mean diagnostic age was 13 ± 4.12 years-old and 90.7% are females. Serum levels of VEGF, Tie2, thrombomodulin were significantly higher while serum ADAMTS13 was lower in active pSLE patients when compared to those with inactive diseases (all
Endothelial dysregulation associating proteins seems to be potent biomarkers for pSLE activity as well as organ involvement in pSLE patients. These biomarkers may be beneficial in understanding of the vascular pathogenesis and disease monitoring.
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DOI: 10.1186/s12969-019-0369-7
PubMed: 31651352
PubMed Central: 6814049
Affiliations:
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xml:lang="en" level="a" type="main">Biomarkers associating endothelial Dysregulation in pediatric-onset systemic lupus erythematous</title><author><name sortKey="Lee, Wan Fang" sort="Lee, Wan Fang" uniqKey="Lee W" first="Wan-Fang" last="Lee">Wan-Fang Lee</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1756 999X</institution-id><institution-id institution-id-type="GRID">grid.454211.7</institution-id><institution>Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics,</institution><institution>Chang Gung Memorial Hospital Linko branch,</institution></institution-wrap>Taoyuan, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taoyuan</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Chao Yi" sort="Wu, Chao Yi" uniqKey="Wu C" first="Chao-Yi" last="Wu">Chao-Yi Wu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id 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Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taoyuan</wicri:regionArea></affiliation></author><author><name sortKey="Ou, Liang Shiou" sort="Ou, Liang Shiou" uniqKey="Ou L" first="Liang-Shiou" last="Ou">Liang-Shiou Ou</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1756 999X</institution-id><institution-id institution-id-type="GRID">grid.454211.7</institution-id><institution>Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics,</institution><institution>Chang Gung Memorial Hospital Linko branch,</institution></institution-wrap>Taoyuan, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taoyuan</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Jing Long" sort="Huang, Jing Long" uniqKey="Huang J" first="Jing-Long" last="Huang">Jing-Long Huang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1756 999X</institution-id><institution-id institution-id-type="GRID">grid.454211.7</institution-id><institution>Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics,</institution><institution>Chang Gung Memorial Hospital Linko branch,</institution></institution-wrap>Taoyuan, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taoyuan</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.145695.a</institution-id><institution>Chang Gung University, College of Medicine,</institution></institution-wrap>Taoyuan, Taiwan</nlm:aff><country xml:lang="fr">Taïwan</country><wicri:regionArea>Taoyuan</wicri:regionArea></affiliation></author></analytic><series><title level="j">Pediatric Rheumatology Online Journal</title><idno type="eISSN">1546-0096</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background/purpose</title><p id="Par1">Endothelium is a key element in the regulation of vascular homeostasis and its alteration can lead to the development of vascular diseases. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with potential extensive vascular lesions, involving skin vessels, renal glomeruli, cardiovascular system, brain, lung alveoli, gastrointestinal tract vessels and more. We aimed to assess endothelial dysregulation related biomarkers in pediatric-onset SLE (pSLE) patient serum and elucidate its correlation with their clinical features, laboratory parameters, and the overall disease activity.</p></sec><sec><title>Methods</title><p id="Par2">Disease activities were evaluated by SLE disease activity index (SLEDAI). Patient characteristics were obtained by retrospective chart review. Six biomarkers associated with endothelial dysregulation, including Angiopoietin-1 (Ang-1), Angiopoietin-2 (Ang-2), Tie2, Vascular endothelial growth facto<bold>r</bold> (VEGF), thrombomodulin, and a disintegrin-like and metalloprotease with thrombospondin type 1 motif (ADAMTS13) were tested through enzyme-linked immunosorbent assay (ELISA) measurement.</p></sec><sec><title>Results</title><p id="Par3">This study comprised 118 pSLE patients. Data from 40 age-matched healthy controls were also obtained. The mean diagnostic age was 13 ± 4.12 years-old and 90.7% are females. Serum levels of VEGF, Tie2, thrombomodulin were significantly higher while serum ADAMTS13 was lower in active pSLE patients when compared to those with inactive diseases (all <italic>p</italic> < 0.05). In organ specific association, serum thrombomodulin level was higher in pSLE patient with renal involvement, and serum ADAMTS13 levels was negatively associated with neurological involvement (<italic>p</italic> < 0.05). A cutoff of thrombomodulin at 3333.6 pg/ml best correlated renal involvement. (AUC = 0.752, <italic>p</italic> < 0.01).</p></sec><sec><title>Conclusion</title><p id="Par4">Endothelial dysregulation associating proteins seems to be potent biomarkers for pSLE activity as well as organ involvement in pSLE patients. These biomarkers may be beneficial in understanding of the vascular pathogenesis and disease monitoring.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cie Lik, P" uniqKey="Cie Lik P">P Cieślik</name></author><author><name sortKey="Hrycek, A" uniqKey="Hrycek A">A Hrycek</name></author><author><name sortKey="Kluci Ski, P" uniqKey="Kluci Ski P">P Kłuciński</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="D Cruz, D" uniqKey="D Cruz D">D D'Cruz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaplan, Mj" uniqKey="Kaplan M">MJ Kaplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chung, Jw" uniqKey="Chung J">JW Chung</name></author><author><name sortKey="Oh, Mj" uniqKey="Oh M">MJ Oh</name></author><author><name sortKey="Cho, Yh" uniqKey="Cho Y">YH Cho</name></author><author><name sortKey="Moon, Gj" uniqKey="Moon G">GJ Moon</name></author><author><name sortKey="Kim, Gm" uniqKey="Kim G">GM Kim</name></author><author><name sortKey="Chung, Cs" uniqKey="Chung C">CS Chung</name></author><author><name sortKey="Lee, Kh" uniqKey="Lee K">KH Lee</name></author><author><name sortKey="Bang, Oy" uniqKey="Bang O">OY Bang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corban, Mt" uniqKey="Corban M">MT Corban</name></author><author><name sortKey="Duarte Garcia, A" uniqKey="Duarte Garcia A">A Duarte-Garcia</name></author><author><name sortKey="Mcbane, Rd" uniqKey="Mcbane R">RD McBane</name></author><author><name sortKey="Matteson, El" uniqKey="Matteson E">EL Matteson</name></author><author><name sortKey="Lerman, Lo" uniqKey="Lerman L">LO Lerman</name></author><author><name sortKey="Lerman, A" uniqKey="Lerman A">A Lerman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kello, Nina" uniqKey="Kello N">Nina Kello</name></author><author><name sortKey="Khoury, Lara El" uniqKey="Khoury L">Lara El Khoury</name></author><author><name sortKey="Marder, Galina" uniqKey="Marder G">Galina Marder</name></author><author><name sortKey="Furie, Richard" uniqKey="Furie R">Richard Furie</name></author><author><name sortKey="Zapantis, Ekaterini" uniqKey="Zapantis E">Ekaterini Zapantis</name></author><author><name sortKey="Horowitz, Diane Lewis" uniqKey="Horowitz D">Diane Lewis Horowitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewandowski, Lb" uniqKey="Lewandowski L">LB Lewandowski</name></author><author><name sortKey="Kaplan, Mj" uniqKey="Kaplan M">MJ Kaplan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcglasson, S" uniqKey="Mcglasson S">S McGlasson</name></author><author><name sortKey="Wiseman, S" uniqKey="Wiseman S">S Wiseman</name></author><author><name sortKey="Wardlaw, J" uniqKey="Wardlaw J">J Wardlaw</name></author><author><name sortKey="Dhaun, N" uniqKey="Dhaun N">N Dhaun</name></author><author><name sortKey="Hunt, Dpj" uniqKey="Hunt D">DPJ Hunt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kamphuis, S" uniqKey="Kamphuis S">S Kamphuis</name></author><author><name sortKey="Silverman, Ed" uniqKey="Silverman E">ED Silverman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tucker, Lb" uniqKey="Tucker L">LB Tucker</name></author><author><name sortKey="Uribe, Ag" uniqKey="Uribe A">AG Uribe</name></author><author><name sortKey="Fernandez, M" uniqKey="Fernandez M">M Fernández</name></author><author><name sortKey="Vila, L" uniqKey="Vila L">L Vilá</name></author><author><name sortKey="Mcgwin, G" uniqKey="Mcgwin G">G McGwin</name></author><author><name sortKey="Apte, M" uniqKey="Apte M">M Apte</name></author><author><name sortKey="Fessler, Hm" uniqKey="Fessler H">HM Fessler</name></author><author><name sortKey="Bastian, B" uniqKey="Bastian B">B Bastian</name></author><author><name sortKey="Reveille, J" uniqKey="Reveille J">J Reveille</name></author><author><name sortKey="Alarc N, G" uniqKey="Alarc N G">G Alarcón</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ambrose, N" uniqKey="Ambrose N">N Ambrose</name></author><author><name sortKey="Morgan, Ta" uniqKey="Morgan T">TA Morgan</name></author><author><name sortKey="Galloway, J" uniqKey="Galloway J">J Galloway</name></author><author><name sortKey="Ionnoau, Y" uniqKey="Ionnoau Y">Y Ionnoau</name></author><author><name sortKey="Beresford, Mw" uniqKey="Beresford M">MW Beresford</name></author><author><name sortKey="Isenberg, Da" uniqKey="Isenberg D">DA Isenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruce, In" uniqKey="Bruce I">IN Bruce</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Kh" uniqKey="Park K">KH Park</name></author><author><name sortKey="Park, Wj" uniqKey="Park W">WJ Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Favero, G" uniqKey="Favero G">G Favero</name></author><author><name sortKey="Paganelli, C" uniqKey="Paganelli C">C Paganelli</name></author><author><name sortKey="Buffoli, B" uniqKey="Buffoli B">B Buffoli</name></author><author><name sortKey="Rodella, Lf" uniqKey="Rodella L">LF Rodella</name></author><author><name sortKey="Rezzani, R" uniqKey="Rezzani R">R Rezzani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hochberg, Mc" uniqKey="Hochberg M">MC Hochberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Griffiths, B" uniqKey="Griffiths B">B Griffiths</name></author><author><name sortKey="Mosca, M" uniqKey="Mosca M">M Mosca</name></author><author><name sortKey="Gordon, C" uniqKey="Gordon C">C Gordon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gladman, Dd" uniqKey="Gladman D">DD Gladman</name></author><author><name sortKey="Ibanez, D" uniqKey="Ibanez D">D Ibanez</name></author><author><name sortKey="Urowitz, Mb" uniqKey="Urowitz M">MB Urowitz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rekvig, Op" uniqKey="Rekvig O">OP Rekvig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davis, P" uniqKey="Davis P">P Davis</name></author><author><name sortKey="Cumming, Rh" uniqKey="Cumming R">RH Cumming</name></author><author><name sortKey="Verrier Jones, J" uniqKey="Verrier Jones J">J Verrier-Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Venner, Aa" uniqKey="Venner A">AA Venner</name></author><author><name sortKey="Ibanez, D" uniqKey="Ibanez D">D Ibanez</name></author><author><name sortKey="Gladman, Dd" uniqKey="Gladman D">DD Gladman</name></author><author><name sortKey="Urowitz, Mb" uniqKey="Urowitz M">MB Urowitz</name></author><author><name sortKey="Mackinnon, A" uniqKey="Mackinnon A">A MacKinnon</name></author><author><name sortKey="Blasutig, Im" uniqKey="Blasutig I">IM Blasutig</name></author><author><name sortKey="Yip, Pm" uniqKey="Yip P">PM Yip</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Linnik, Md" uniqKey="Linnik M">MD Linnik</name></author><author><name sortKey="Hu, Jz" uniqKey="Hu J">JZ Hu</name></author><author><name sortKey="Heilbrunn, Kr" uniqKey="Heilbrunn K">KR Heilbrunn</name></author><author><name sortKey="Strand, V" uniqKey="Strand V">V Strand</name></author><author><name sortKey="Hurley, Fl" uniqKey="Hurley F">FL Hurley</name></author><author><name sortKey="Joh, T" uniqKey="Joh T">T Joh</name></author><author><name sortKey="Consortium, Ljpi" uniqKey="Consortium L">LJPI Consortium</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fiedler, U" uniqKey="Fiedler U">U Fiedler</name></author><author><name sortKey="Augustin, Hg" uniqKey="Augustin H">HG Augustin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thurston, G" uniqKey="Thurston G">G Thurston</name></author><author><name sortKey="Rudge, Js" uniqKey="Rudge J">JS Rudge</name></author><author><name sortKey="Ioffe, E" uniqKey="Ioffe E">E Ioffe</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name></author><author><name sortKey="Ross, L" uniqKey="Ross L">L Ross</name></author><author><name sortKey="Croll, Sd" uniqKey="Croll S">SD Croll</name></author><author><name sortKey="Glazer, N" uniqKey="Glazer N">N Glazer</name></author><author><name sortKey="Holash, J" uniqKey="Holash J">J Holash</name></author><author><name sortKey="Mcdonald, Dm" uniqKey="Mcdonald D">DM McDonald</name></author><author><name sortKey="Yancopoulos, Gd" uniqKey="Yancopoulos G">GD Yancopoulos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ross, Russell" uniqKey="Ross R">Russell Ross</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Kw" uniqKey="Lee K">KW Lee</name></author><author><name sortKey="Lip, Gy" uniqKey="Lip G">GY Lip</name></author><author><name sortKey="Blann, Ad" uniqKey="Blann A">AD Blann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roman, Mj" uniqKey="Roman M">MJ Roman</name></author><author><name sortKey="Crow, Mk" uniqKey="Crow M">MK Crow</name></author><author><name sortKey="Lockshin, Md" uniqKey="Lockshin M">MD Lockshin</name></author><author><name sortKey="Devereux, Rb" uniqKey="Devereux R">RB Devereux</name></author><author><name sortKey="Paget, Sa" uniqKey="Paget S">SA Paget</name></author><author><name sortKey="Sammaritano, L" uniqKey="Sammaritano L">L Sammaritano</name></author><author><name sortKey="Levine, Dm" uniqKey="Levine D">DM Levine</name></author><author><name sortKey="Davis, A" uniqKey="Davis A">A Davis</name></author><author><name sortKey="Salmon, Je" uniqKey="Salmon J">JE Salmon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Manger, K" uniqKey="Manger K">K Manger</name></author><author><name sortKey="Kusus, M" uniqKey="Kusus M">M Kusus</name></author><author><name sortKey="Forster, C" uniqKey="Forster C">C Forster</name></author><author><name sortKey="Ropers, D" uniqKey="Ropers D">D Ropers</name></author><author><name sortKey="Daniel, Wg" uniqKey="Daniel W">WG Daniel</name></author><author><name sortKey="Kalden, Jr" uniqKey="Kalden J">JR Kalden</name></author><author><name sortKey="Achenbach, S" uniqKey="Achenbach S">S Achenbach</name></author><author><name sortKey="Manger, B" uniqKey="Manger B">B Manger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Heshmat, Nm" uniqKey="Heshmat N">NM Heshmat</name></author><author><name sortKey="El Kerdany, Th" uniqKey="El Kerdany T">TH El-Kerdany</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Navarro, C" uniqKey="Navarro C">C Navarro</name></author><author><name sortKey="Candia Zuniga, L" uniqKey="Candia Zuniga L">L Candia-Zuniga</name></author><author><name sortKey="Silveira, Lh" uniqKey="Silveira L">LH Silveira</name></author><author><name sortKey="Ruiz, V" uniqKey="Ruiz V">V Ruiz</name></author><author><name sortKey="Gaxiola, M" uniqKey="Gaxiola M">M Gaxiola</name></author><author><name sortKey="Avila, Mc" uniqKey="Avila M">MC Avila</name></author><author><name sortKey="Amigo, Mc" uniqKey="Amigo M">MC Amigo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, Mh" uniqKey="Liang M">MH Liang</name></author><author><name sortKey="Socher, Sa" uniqKey="Socher S">SA Socher</name></author><author><name sortKey="Larson, Mg" uniqKey="Larson M">MG Larson</name></author><author><name sortKey="Schur, Ph" uniqKey="Schur P">PH Schur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boehme, Mw" uniqKey="Boehme M">MW Boehme</name></author><author><name sortKey="Raeth, U" uniqKey="Raeth U">U Raeth</name></author><author><name sortKey="Galle, Pr" uniqKey="Galle P">PR Galle</name></author><author><name sortKey="Stremmel, W" uniqKey="Stremmel W">W Stremmel</name></author><author><name sortKey="Scherbaum, Wa" uniqKey="Scherbaum W">WA Scherbaum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kiraz, S" uniqKey="Kiraz S">S Kiraz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Gamal, Ym" uniqKey="El Gamal Y">YM el-Gamal</name></author><author><name sortKey="Heshmat, Nm" uniqKey="Heshmat N">NM Heshmat</name></author><author><name sortKey="El Kerdany, Th" uniqKey="El Kerdany T">TH el-Kerdany</name></author><author><name sortKey="Fawzy, Af" uniqKey="Fawzy A">AF Fawzy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Furlan, M" uniqKey="Furlan M">M Furlan</name></author><author><name sortKey="Robles, R" uniqKey="Robles R">R Robles</name></author><author><name sortKey="Galbusera, M" uniqKey="Galbusera M">M Galbusera</name></author><author><name sortKey="Remuzzi, G" uniqKey="Remuzzi G">G Remuzzi</name></author><author><name sortKey="Kyrle, Pa" uniqKey="Kyrle P">PA Kyrle</name></author><author><name sortKey="Brenner, B" uniqKey="Brenner B">B Brenner</name></author><author><name sortKey="Krause, M" uniqKey="Krause M">M Krause</name></author><author><name sortKey="Scharrer, I" uniqKey="Scharrer I">I Scharrer</name></author><author><name sortKey="Aumann, V" uniqKey="Aumann V">V Aumann</name></author><author><name sortKey="Mittler, U" uniqKey="Mittler U">U Mittler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moake, Jl" uniqKey="Moake J">JL Moake</name></author><author><name sortKey="Turner, Na" uniqKey="Turner N">NA Turner</name></author><author><name sortKey="Stathopoulos, Na" uniqKey="Stathopoulos N">NA Stathopoulos</name></author><author><name sortKey="Nolasco, Lh" uniqKey="Nolasco L">LH Nolasco</name></author><author><name sortKey="Hellums, Jd" uniqKey="Hellums J">JD Hellums</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin Rodriguez, S" uniqKey="Martin Rodriguez S">S Martin-Rodriguez</name></author><author><name sortKey="Reverter, Jc" uniqKey="Reverter J">JC Reverter</name></author><author><name sortKey="Tassies, D" uniqKey="Tassies D">D Tassies</name></author><author><name sortKey="Espinosa, G" uniqKey="Espinosa G">G Espinosa</name></author><author><name sortKey="Heras, M" uniqKey="Heras M">M Heras</name></author><author><name sortKey="Pino, M" uniqKey="Pino M">M Pino</name></author><author><name sortKey="Escolar, G" uniqKey="Escolar G">G Escolar</name></author><author><name sortKey="Diaz Ricart, M" uniqKey="Diaz Ricart M">M Diaz-Ricart</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="De Leeuw, K" uniqKey="De Leeuw K">K de Leeuw</name></author><author><name sortKey="Freire, B" uniqKey="Freire B">B Freire</name></author><author><name sortKey="Smit, Aj" uniqKey="Smit A">AJ Smit</name></author><author><name sortKey="Bootsma, H" uniqKey="Bootsma H">H Bootsma</name></author><author><name sortKey="Kallenberg, Cg" uniqKey="Kallenberg C">CG Kallenberg</name></author><author><name sortKey="Bijl, M" uniqKey="Bijl M">M Bijl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mok, Cc" uniqKey="Mok C">CC Mok</name></author><author><name sortKey="Tang, Ss" uniqKey="Tang S">SS Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mok, Cc" uniqKey="Mok C">CC Mok</name></author><author><name sortKey="Kwok, Rc" uniqKey="Kwok R">RC Kwok</name></author><author><name sortKey="Yip, Ps" uniqKey="Yip P">PS Yip</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewis, Ej" uniqKey="Lewis E">EJ Lewis</name></author><author><name sortKey="Schwartz, Mm" uniqKey="Schwartz M">MM Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kumpers, P" uniqKey="Kumpers P">P Kumpers</name></author><author><name sortKey="David, S" uniqKey="David S">S David</name></author><author><name sortKey="Haubitz, M" uniqKey="Haubitz M">M Haubitz</name></author><author><name sortKey="Hellpap, J" uniqKey="Hellpap J">J Hellpap</name></author><author><name sortKey="Horn, R" uniqKey="Horn R">R Horn</name></author><author><name sortKey="Brocker, V" uniqKey="Brocker V">V Brocker</name></author><author><name sortKey="Schiffer, M" uniqKey="Schiffer M">M Schiffer</name></author><author><name sortKey="Haller, H" uniqKey="Haller H">H Haller</name></author><author><name sortKey="Witte, T" uniqKey="Witte T">T Witte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brown, Lf" uniqKey="Brown L">LF Brown</name></author><author><name sortKey="Berse, B" uniqKey="Berse B">B Berse</name></author><author><name sortKey="Tognazzi, K" uniqKey="Tognazzi K">K Tognazzi</name></author><author><name sortKey="Manseau, Ej" uniqKey="Manseau E">EJ Manseau</name></author><author><name sortKey="Van De Water, L" uniqKey="Van De Water L">L Van de Water</name></author><author><name sortKey="Senger, Dr" uniqKey="Senger D">DR Senger</name></author><author><name sortKey="Dvorak, Hf" uniqKey="Dvorak H">HF Dvorak</name></author><author><name sortKey="Rosen, S" uniqKey="Rosen S">S Rosen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shulman, K" uniqKey="Shulman K">K Shulman</name></author><author><name sortKey="Rosen, S" uniqKey="Rosen S">S Rosen</name></author><author><name sortKey="Tognazzi, K" uniqKey="Tognazzi K">K Tognazzi</name></author><author><name sortKey="Manseau, Ej" uniqKey="Manseau E">EJ Manseau</name></author><author><name sortKey="Brown, Lf" uniqKey="Brown L">LF Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coimbra, Tm" uniqKey="Coimbra T">TM Coimbra</name></author><author><name sortKey="Janssen, U" uniqKey="Janssen U">U Janssen</name></author><author><name sortKey="Grone, Hj" uniqKey="Grone H">HJ Grone</name></author><author><name sortKey="Ostendorf, T" uniqKey="Ostendorf T">T Ostendorf</name></author><author><name sortKey="Kunter, U" uniqKey="Kunter U">U Kunter</name></author><author><name sortKey="Schmidt, H" uniqKey="Schmidt H">H Schmidt</name></author><author><name sortKey="Brabant, G" uniqKey="Brabant G">G Brabant</name></author><author><name sortKey="Floege, J" uniqKey="Floege J">J Floege</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Witte, T" uniqKey="Witte T">T Witte</name></author><author><name sortKey="Hartung, K" uniqKey="Hartung K">K Hartung</name></author><author><name sortKey="Sachse, C" uniqKey="Sachse C">C Sachse</name></author><author><name sortKey="Fricke, M" uniqKey="Fricke M">M Fricke</name></author><author><name sortKey="Buyny, S" uniqKey="Buyny S">S Buyny</name></author><author><name sortKey="Deicher, H" uniqKey="Deicher H">H Deicher</name></author><author><name sortKey="Kalden, Jr" uniqKey="Kalden J">JR Kalden</name></author><author><name sortKey="Lakomek, Hj" uniqKey="Lakomek H">HJ Lakomek</name></author><author><name sortKey="Peter, Hh" uniqKey="Peter H">HH Peter</name></author><author><name sortKey="Schmidt, Re" uniqKey="Schmidt R">RE Schmidt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drozdz, D" uniqKey="Drozdz D">D Drozdz</name></author><author><name sortKey="Latka, M" uniqKey="Latka M">M Latka</name></author><author><name sortKey="Drozdz, T" uniqKey="Drozdz T">T Drozdz</name></author><author><name sortKey="Sztefko, K" uniqKey="Sztefko K">K Sztefko</name></author><author><name sortKey="Kwinta, P" uniqKey="Kwinta P">P Kwinta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borchers, At" uniqKey="Borchers A">AT Borchers</name></author><author><name sortKey="Leibushor, N" uniqKey="Leibushor N">N Leibushor</name></author><author><name sortKey="Naguwa, Sm" uniqKey="Naguwa S">SM Naguwa</name></author><author><name sortKey="Cheema, Gs" uniqKey="Cheema G">GS Cheema</name></author><author><name sortKey="Shoenfeld, Y" uniqKey="Shoenfeld Y">Y Shoenfeld</name></author><author><name sortKey="Gershwin, Me" uniqKey="Gershwin M">ME Gershwin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weening, Jj" uniqKey="Weening J">JJ Weening</name></author><author><name sortKey="D Agati, Vd" uniqKey="D Agati V">VD D'Agati</name></author><author><name sortKey="Schwartz, Mm" uniqKey="Schwartz M">MM Schwartz</name></author><author><name sortKey="Seshan, Sv" uniqKey="Seshan S">SV Seshan</name></author><author><name sortKey="Alpers, Ce" uniqKey="Alpers C">CE Alpers</name></author><author><name sortKey="Appel, Gb" uniqKey="Appel G">GB Appel</name></author><author><name sortKey="Balow, Je" uniqKey="Balow J">JE Balow</name></author><author><name sortKey="Bruijn, Ja" uniqKey="Bruijn J">JA Bruijn</name></author><author><name sortKey="Cook, T" uniqKey="Cook T">T Cook</name></author><author><name sortKey="Ferrario, F" uniqKey="Ferrario F">F Ferrario</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tay, Sh" uniqKey="Tay S">SH Tay</name></author><author><name sortKey="Mak, A" uniqKey="Mak A">A Mak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lefevre, G" uniqKey="Lefevre G">G Lefevre</name></author><author><name sortKey="Zephir, H" uniqKey="Zephir H">H Zephir</name></author><author><name sortKey="Warembourg, F" uniqKey="Warembourg F">F Warembourg</name></author><author><name sortKey="Michelin, E" uniqKey="Michelin E">E Michelin</name></author><author><name sortKey="Pruvo, Jp" uniqKey="Pruvo J">JP Pruvo</name></author><author><name sortKey="Hachulla, E" uniqKey="Hachulla E">E Hachulla</name></author><author><name sortKey="Semah, F" uniqKey="Semah F">F Semah</name></author><author><name sortKey="Dubucquoi, S" uniqKey="Dubucquoi S">S Dubucquoi</name></author><author><name sortKey="Lenfant, P" uniqKey="Lenfant P">P Lenfant</name></author><author><name sortKey="Vermersch, P" uniqKey="Vermersch P">P Vermersch</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Lee, Wan Fang" sort="Lee, Wan Fang" uniqKey="Lee W" first="Wan-Fang" last="Lee">Wan-Fang Lee</name></noRegion><name sortKey="Chen, Li Chen" sort="Chen, Li Chen" uniqKey="Chen L" first="Li-Chen" last="Chen">Li-Chen Chen</name><name sortKey="Huang, Jing Long" sort="Huang, Jing Long" uniqKey="Huang J" first="Jing-Long" last="Huang">Jing-Long Huang</name><name sortKey="Huang, Jing Long" sort="Huang, Jing Long" uniqKey="Huang J" first="Jing-Long" last="Huang">Jing-Long Huang</name><name sortKey="Lee, Wen I" sort="Lee, Wen I" uniqKey="Lee W" first="Wen-I" last="Lee">Wen-I Lee</name><name sortKey="Ou, Liang Shiou" sort="Ou, Liang Shiou" uniqKey="Ou L" first="Liang-Shiou" last="Ou">Liang-Shiou Ou</name><name sortKey="Wu, Chao Yi" sort="Wu, Chao Yi" uniqKey="Wu C" first="Chao-Yi" last="Wu">Chao-Yi Wu</name><name sortKey="Wu, Chao Yi" sort="Wu, Chao Yi" uniqKey="Wu C" first="Chao-Yi" last="Wu">Chao-Yi Wu</name><name sortKey="Yang, Huang Yu" sort="Yang, Huang Yu" uniqKey="Yang H" first="Huang-Yu" last="Yang">Huang-Yu Yang</name><name sortKey="Yang, Huang Yu" sort="Yang, Huang Yu" uniqKey="Yang H" first="Huang-Yu" last="Yang">Huang-Yu Yang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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